Comprehensive Nursing Pharmacology Q 255

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The nurse is reviewing the client’s history who is about to take Methotrexate. Which of the following drugs can be safely administered together with methotrexate?

  

     A. Tetracycline

     B. Folic Acid

     C. Sulfamethoxazole

     D. Phenytoin

    

    

Correct Answer: B. Folic Acid

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Clients who take folic acid supplements lowered the risk of GI problems and mouth sores brought about by the use of methotrexate.

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Option A: Tetracycline may decrease intestinal absorption of methotrexate.

Options C and D: Methotrexate is partially bound to serum albumin, and toxicity may be increased because of displacement by certain drugs, such as salicylates, phenylbutazone, phenytoin, and sulfonamides.

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