Gastrointestinal Drugs and Medications Q 9

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A client with a history of chest pain is admitted to irritable bowel syndrome. As a nurse, which of the following medicines will you least expect to be a part of the medical management?

  

     A. alosetron (Lotronex)

     B. tegaserod (Zelnorm)

     C. lubiprostone (Amitiza)

     D. loperamide (Imodium)

    

    

Correct Answer: B. Tegaserod (Zelnorm).

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The use of tegaserod is restricted to patients with IBS due to the serious cardiovascular adverse effect that may happen such as heart attack and stroke.

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Option A: Alosetron (Lotronex) is a selective 5-HT3 receptor antagonist used specifically for women with irritable bowel syndromes.

Option B: Tegaserod (Zelnorm) is a serotonin type 4 receptor partial agonist used for women below 65 years old who have irritable bowel syndrome with constipation.

Option C: Lubiprostone (Amitiza) is a chloride channel activator used to treat irritable bowel syndrome with constipation among women 18 years of age and older.

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