Psychiatric Drugs and Medications Q 27

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Amphetamines and amphetamine-like compounds are most commonly used for:

  

     A. Narcolepsy

     B. Attention deficit disorder

     C. Exogenous obesity

     D. All of the above

    

    

Correct Answer: D. All of the above

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The most common uses of amphetamines and amphetamine-like compounds are narcolepsy, exogenous obesity, and attention deficit disorder. Amphetamine is FDA-approved for the treatment of attention-deficit/hyperactivity disorder (ADHD) and narcolepsy. It has indications as a first-line agent for ADHD in adults and children six years of age and older. Amphetamine is also a second-line agent for the treatment of narcolepsy.

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Option A: Patients with narcolepsy generally benefit from divided doses and may require an early afternoon dose to control daytime sleepiness. Dosages usually range from 5 mg to 40 mg daily and should not exceed 60 mg, which is the maximum dose for certain adults.

Option B: The choice of agent for initial therapy is based on cost, patient preference, and concern for abuse. Dextroamphetamine is the only amphetamine medication FDA-approved for use in children younger than six years, but most current guidelines recommend behavioral therapy alone in preschool-aged children with ADHD symptoms.

Option C: Lisdexamfetamine, a long-acting amphetamine medication, is FDA-approved for the treatment of a binge-eating disorder. Lisdexamfetamine may be preferred if there is increased concern for abuse by the patient or a household member, as its chemically-phased release allows for once-daily dosing and may theoretically deter abuse. Lisdexamfetamine is available as capsules or chewable tablets, and typical daily dosages range from 20 mg to 70 mg.

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