Cardiovascular Drugs and Medications Q 38

---

The drug/drugs used most commonly to treat peripheral or cerebral vascular obstructive disease is/are:

  

     A. pentoxifylline (Trental)

     B. cyclandelate (Cyclan)

     C. isoxsuprine (Vasodilan)

     D. All of the above

    

    

Correct Answer: D. All of the above

---

All are vasodilators used primarily to treat peripheral or cerebral vascular obstructive disease. There are different classes of vasodilators used today in the current clinical practice, and each has different actions on the coronary arteries and peripheral vasculature (arteries and veins). Vasodilators most commonly affect the arteries in the human body, but some vasodilators (such as nitroglycerin) can affect the venous system of the body predominantly.

---

Option A: Pentoxifylline (PTXF) is a vasoactive agent that improves the flow of blood by reducing its viscosity. Pentoxifylline and its metabolites decrease blood viscosity and improve the blood flow and peripheral tissue oxygenation.

Option B: Cyclandelate belongs to the group of medicines commonly called vasodilators. These medicines increase the size of blood vessels. Cyclandelate is used to treat problems resulting from poor blood circulation.

Option C: Isoxsuprine (Vasodilan) is a beta-adrenergic that directly affects the vascular smooth muscle and results in peripheral vascular dilation. Isoxsuprine relaxes the uterine smooth muscles and is used for the treatment of pre-term labor and dysmenorrhea.

---