Comprehensive Nursing Pharmacology Q 169

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Arvic, a 16-year-old student, has acquired systemic fungal infection, he should be treated with:

  

     A. Amphotericin B (Fungizone)

     B. Miconazole (Monistat IV)

     C. Ketoconazole (Nizoral)

     D. Griseofulvin (Fulvicin)

    

    

Correct Answer: A. Amphotericin B (Fungizone)

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Serious life-threatening fungal infections are treated with amphotericin B. Amphotericin B deoxycholate belongs to the polyene class of antifungals. It is also known by the name conventional amphotericin B and has been in use for the treatment of invasive fungal infections for more than 50 years. It was first isolated as a natural product of a soil actinomycete.

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Option B: Topical miconazole is approved to treat cutaneous and mucocutaneous mycoses, particularly vulvovaginal candidiasis. Oral formulations of miconazole are indicated for oropharyngeal candidiasis.

Option C: Ketoconazole, when applied topically, has been approved for treating tinea corporis, tinea cruris, tinea pedis, tinea versicolor, cutaneous candidiasis, and seborrheic dermatitis. Off-label, topical ketoconazole is used to treat several oral candidal pathologies, including chronic mucocutaneous candidiasis and oral thrush.

Option D: Griseofulvin is only approved as a systemic (oral) agent and is indicated for the treatment of dermatophytoses of the skin, hair, and nails, which is severe or refractory to topical therapy. Specifically, this drug treats tinea (corporis, pedis, cruris, barbae, capitis, and unguium).

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