Comprehensive Nursing Pharmacology Q 192

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Amphotericin B (Fungizone) IV is given to a client with aspergillosis, a fungal infection. In order to prevent its side effects, the nurse anticipates administering which of the following prior, except?

  

     A. Hydrocortisone.

     B. Ketoconazole.

     C. Diphenhydramine.

     D. Meperidine.

    

    

Correct Answer: B. Ketoconazole

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Azole antifungals (eg, ketoconazole) decreases the effectiveness of amphotericin b.

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Options A and C: Fever, shaking, chills, flushing, loss of appetite, dizziness, nausea, vomiting, headache, shortness of breath, or fast breathing may occur 1 to 3 hours after the infusion is started. Medications such as acetaminophen, diphenhydramine, corticosteroids such as hydrocortisone) may be necessary to prevent these side effects.

Option D: Meperidine (25 to 50 mg IV) has been shown in some patients to decrease the duration of shaking chills and fever that may accompany the infusion of amphotericin B.

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