Comprehensive Nursing Pharmacology Q 53

---

Mannitol (Osmitrol), an osmotic diuretic, is contraindicated to which conditions? Select all that apply.

  

     A. Pulmonary edema

     B. Narrow-angle glaucoma

     C. Heart failure

     D. Chemotherapy

     E. Hyponatremia

    

Correct Answer: A, C, and E

---

Too rapid infusion of large amounts of mannitol injection will cause a shift of intracellular water into the extracellular compartment resulting in cellular dehydration and overexpansion of the intravascular space with hyponatremia, congestive heart failure, and pulmonary edema.

---

Option B: Mannitol is used to decrease ICP in clients with narrow-angle glaucoma.

Option D: Mannitol is used with chemotherapy to induce diuresis.

---